[Involvement of the VEGF-Flt-receptor family in angiogenesis].

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  • Author(s): Shibuya M;Shibuya M
  • Source:
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica [Nihon Yakurigaku Zasshi] 1996 Mar; Vol. 107 (3), pp. 119-31.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Nippon Yakuri Gakkai Country of Publication: Japan NLM ID: 0420550 Publication Model: Print Cited Medium: Print ISSN: 0015-5691 (Print) Linking ISSN: 00155691 NLM ISO Abbreviation: Nihon Yakurigaku Zasshi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo, Nippon Yakuri Gakkai.
    • Subject Terms:
      Endothelial Growth Factors*/genetics ; Endothelial Growth Factors*/physiology ; Lymphokines*/genetics ; Lymphokines*/physiology ; Receptor Protein-Tyrosine Kinases*/physiology ; Receptors, Growth Factor*/physiology; Amino Acid Sequence ; Animals ; Gene Expression Regulation ; Humans ; Molecular Sequence Data ; Neovascularization, Pathologic ; Receptors, Vascular Endothelial Growth Factor ; Signal Transduction ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
    • Abstract:
      Angiogenesis is important not only in normal embryogenesis, tissue organization and its maintenance but also in pathological processes such as ocular disease in diabetes mellitus and rapid growth of tumors in vivo. Recently, endothelial cell-specific growth factor (VEGF) and its receptors (Flt family) has been characterized, and this ligand-tyrosine kinase receptor is considered to be one of the most important systems involved in angiogenesis. VEGF is induced by a variety of normal or tumor cells under conditions such as hypoxia and hypoglycemia and in the presence of substances such as hormones and growth factors. On the other hand, receptors of the Flt family (Flt-1, KDR/Flk-1, Flt-4) are basically strictly expressed only on vascular endothelial cells with a rare exception. Thus, the stimulation of VEGF-Flt towards angiogenesis is through a paracrine mechanism. A direct involvement of Flt-1 and KDR/Flk-1 in vasculogenesis/angiogenesis has recently been demonstrated by gene targetting studies. Blocking of this system might be a useful tool for suppression of solid tumors in vivo.
    • Number of References:
      44
    • Accession Number:
      0 (Endothelial Growth Factors)
      0 (Lymphokines)
      0 (Receptors, Growth Factor)
      0 (Vascular Endothelial Growth Factor A)
      0 (Vascular Endothelial Growth Factors)
      EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
      EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
    • Publication Date:
      Date Created: 19960301 Date Completed: 19961011 Latest Revision: 20190830
    • Publication Date:
      20240829
    • Accession Number:
      10.1254/fpj.107.119
    • Accession Number:
      8728285