Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice.

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  • Author(s): Waters WR;Waters WR; Harp JA
  • Source:
    Infection and immunity [Infect Immun] 1996 May; Vol. 64 (5), pp. 1854-7.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print Cited Medium: Print ISSN: 0019-9567 (Print) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : American Society For Microbiology
      Original Publication: [Bethesda, Md.] American Society for Microbiology.
    • Subject Terms:
      Cryptosporidium parvum*; Cryptosporidiosis/*immunology ; Receptors, Antigen, T-Cell, alpha-beta/*deficiency ; Receptors, Antigen, T-Cell, gamma-delta/*deficiency; Animals ; Animals, Newborn ; CD4-Positive T-Lymphocytes/immunology ; Chronic Disease ; Cryptosporidiosis/pathology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/genetics
    • Abstract:
      Mice deficient in either alpha beta or gamma delta T cells were more susceptible to infection with the protozoan parasite Cryptosporidium parvum than were control mice. Both neonatal and adult alpha beta-T-cell-deficient mice developed chronic infection. Gamma delta-T-cell-deficient neonatal mice were more susceptible than control mice but were able to clear the infection. Adult gamma delta-T-cell-deficient mice were not susceptible to infection. These data indicate that alpha beta T cells are important for resistance to C. parvum while gamma delta T cells have a less critical role.
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    • Grant Information:
      T32 AI07378 United States AI NIAID NIH HHS
    • Accession Number:
      0 (Receptors, Antigen, T-Cell, alpha-beta)
      0 (Receptors, Antigen, T-Cell, gamma-delta)
    • Publication Date:
      Date Created: 19960501 Date Completed: 19960606 Latest Revision: 20210526
    • Publication Date:
      20240829
    • Accession Number:
      PMC174004
    • Accession Number:
      10.1128/iai.64.5.1854-1857.1996
    • Accession Number:
      8613403