Chalcone-derived thiosemicarbazones and their zinc(II) and gallium(III) complexes: spectral studies and antimicrobial activity.

Chalcone-derived 3-phenyl-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone (HPyCTPh) (1), 3-(4-chlorophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone (HPyCT4ClPh) (2), 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone (HPyCT4BrPh) (3), and 3-(4-nitrophenyl-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone (HPyCT4NO2Ph) (4) were obtained as well as their gallium(III) and zinc(II) complexes [Ga(PyCTPh)2]NO3(Ga1), [Ga(PyCT4ClPh)2]NO3(Ga2), [Ga(PyCT4BrPh)2]NO3(Ga3), [Ga(PyCT4NO2Ph)2]NO3(Ga4), [Zn(PyCTPh)2] (Zn1), [Zn(PyCT4ClPh)2] (Zn2), [Zn(PyCT4BrPh)2] (Zn3), and [Zn(PyCT4NO2Ph)2] (Zn4). The chalcones, thiosemicarbazones, and zinc(II) complexes were not active againstPseudomonas aeruginosa. The thiosemicarbazones proved to be more active than the parent chalcones againstStaphylococcus aureusandCandida albicans. Coordination to zinc(II) resulted in activity improvement of most thiosemicarbazones againstS. aureus. Coordination to gallium(III) significantly improved the antimicrobial activity of all thiosemicarbazones against the studied micro-organisms, suggesting this to be an effective strategy for antimicrobial activity enhancement. [ABSTRACT FROM AUTHOR]

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