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Proteins isolated from the venom of the common tiger snake (Notechis scutatus scutatus) promote hypotension and hemorrhage.
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- Author(s): Francis B;Francis B; Williams ES; Seebart C; Kaiser II
- Source:
Toxicon : official journal of the International Society on Toxinology [Toxicon] 1993 Apr; Vol. 31 (4), pp. 447-58.
- Publication Type:
Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
- Language:
English
- Additional Information
- Source:
Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print Cited Medium: Print ISSN: 0041-0101 (Print) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE
- Publication Information:
Original Publication: Oxford ; New York : Pergamon Press, c1962-
- Subject Terms:
- Abstract:
Notechis scutatus scutatus venom contains several toxic acidic proteins called HTa-i which promote hypotension and hemorrhage in mice. They have apparent mol. wts in the 18,000-21,000 range, i.v. LD50 values between 0.5 and 1.5 micrograms/g, and no detectable phospholipase, arginine esterase, proteolytic or hemolytic activities. A polyclonal antibody raised against HTg binds to other purified proteins, suggesting that they are isoforms of the same protein. Many other elapid crude venoms contain proteins which recognize the polyclonal antibody raised against HTg. Crotalid and viperid crude venoms do not recognize this antibody, although some of their component proteins are known to exhibit hypotensive and hemorrhagic activities. A combination of gel-filtration on Sephacryl S-200, cation-exchange and anion-exchange chromatography allows isolation of the N. s. scutatus proteins in high purity. They are the first hypotension-inducing proteins to be purified from an Australian elapid.
- Accession Number:
0 (Crotalid Venoms)
0 (Elapid Venoms)
0 (Proteins)
0 (Viper Venoms)
- Publication Date:
Date Created: 19930401 Date Completed: 19930628 Latest Revision: 20190821
- Publication Date:
20240829
- Accession Number:
10.1016/0041-0101(93)90180-q
- Accession Number:
8503133
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