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Influence of recombinant bovine somatotropin (sometribove) on mononuclear cells during the nonlactating period.
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- Author(s): Torre PM;Torre PM; Lewis MJ; Ingle TL; Oliver SP
- Source:
Journal of dairy science [J Dairy Sci] 1993 Apr; Vol. 76 (4), pp. 983-91.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: American Dairy Science Association Country of Publication: United States NLM ID: 2985126R Publication Model: Print Cited Medium: Print ISSN: 0022-0302 (Print) Linking ISSN: 00220302 NLM ISO Abbreviation: J Dairy Sci Subsets: MEDLINE
- Publication Information:
Publication: Champaign, IL : American Dairy Science Association
Original Publication: Lancaster, Pa. [etc.]
- Subject Terms:
- Abstract:
Recombinant bST was evaluated as a potential immunoenhancer of bovine peripheral blood and mammary gland mononuclear cells during the nonlactating period. Cows (n = 4 per group) were assigned to one of four treatments: 1) untreated, 2) treated with recombinant bST during lactation only, 3) treated with recombinant bST during the nonlactating period only, and 4) treated with recombinant bST during lactation and the nonlactating period. Recombinant bST treatment during the nonlactating period had no effect on proliferation of bovine blood or mammary gland mononuclear cells in response to stimulation by mitogens or allogeneic cells. Recombinant bST treatment during the nonlactating period enhanced interleukin-2 secretion by mononuclear cells isolated from cows treated also with recombinant bST during lactation. However, recombinant bST treatment during the nonlactating period had little effect on interleukin-2 secretion by mononuclear cells from cows not treated with recombinant bST during lactation. Results of this study suggest that recombinant bST alters effector functions rather than proliferation of bovine mononuclear cells.
- Accession Number:
0 (Interleukin-2)
0 (Recombinant Proteins)
12629-01-5 (Human Growth Hormone)
9002-72-6 (Growth Hormone)
- Publication Date:
Date Created: 19930401 Date Completed: 19930610 Latest Revision: 20061115
- Publication Date:
20240829
- Accession Number:
10.3168/jds.S0022-0302(93)77426-3
- Accession Number:
8486850
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