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Immunotherapy: Immunological bullets against Alzheimer's disease.
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- Author(s): Papatriantafyllou, Maria
- Source:
Nature Reviews Immunology. Jan2013, Vol. 13 Issue 1, p2-3. 2p. 1 Diagram.
- Subject Terms:
- Additional Information
- Abstract:
The article offers information on a study conducted by researchers related to the use of interleukin-12 (IL-12) and IL-23 signalling for treatment of Alzheimer's disease. They analyzed microglia's phenotype from transgenic mice and found increased expression of p40, which is a common subunit of IL-12 and IL-23. It highlights that administration of a p40-specific antibody reduced formation of amyloid-β plaque.
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