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Parallel maternal and fetal immune activation by bacterial toxins in vitro.
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- Author(s): Young, Bruce K.; Li, Xiao; Arslan, Alan A.
- Source:
Journal of Perinatal Medicine; Jan2012, Vol. 40 Issue 1, p73-76, 4p, 2 Charts- Subject Terms:
BACTERIAL toxins; CYTOKINES; IMMUNOREGULATION; PREMATURE infants; PREMATURE labor; BLOODBORNE infections; ESCHERICHIA coli; ACADEMIC medical centers; CONFIDENCE intervals; STATISTICAL correlation; ENDOTOXINS; IMMUNE system; REGRESSION analysis; T-test (Statistics); DATA analysis software; IN vitro studies - Source:
- Additional Information
- Subject Terms:
- Abstract: This study evaluated in vitro immune responses to Escherichia coli lipopolysaccharide in maternal and fetal blood. Samples were concurrently obtained from maternal venipuncture and umbilical cord blood samples and cultured with the E. coli endotoxin, and cytokines were assayed. There were statistically significant correlations between maternal and fetal samples. This demonstrates maternal and fetal immune communication and mutual programming during pregnancy. Subclinical infection, which predisposes to premature labor, could be detectable from a maternal blood sample even if derived only from the fetal compartment. A maternal blood panel test might serve as a diagnostic screen for subclinical infection in patients at risk for preterm labor. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Perinatal Medicine is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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