Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Schott, Jean-Jacques; Benson, D. Woodrow; Basson, Craig T.; Pease, William; Silberbach, G. Michael; Moak, Jeffrey P.; Maron, Barry J.; Seidman, Christine E.; Seidman, J.G.
- Source:
Science. 7/3/1998, Vol. 281 Issue 5373, p108-111. 4p. 2 Color Photographs, 3 Black and White Photographs, 5 Diagrams, 2 Charts, 5 Graphs.
- Additional Information
- Subject Terms:
- Abstract:
Reports on mutations in the gene encoding the homeobox transcription factor NKX2-5 that were found to cause nonsyndromic, human congenital heart disease. Three different NKX2-5 mutations that were identified; Indications of data that NKX2-5 is important for regulation of septation during cardiac morphogenesis and for maturation and maintenance of atrioventricular node function throughout life.
No Comments.