Comparative histologic study of adenomas of the large intestine in Japan and England, with special reference to malignant potential.

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  • Author(s): Muto T; Ishikawa K; Kino I; Nakamura K; Sugano H
  • Source:
    Diseases of the colon and rectum [Dis Colon Rectum] 1977 Jan-Feb; Vol. 20 (1), pp. 11-6.
  • Publication Type:
    Comparative Study; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Lippincott Country of Publication: United States NLM ID: 0372764 Publication Model: Print Cited Medium: Print ISSN: 0012-3706 (Print) Linking ISSN: 00123706 NLM ISO Abbreviation: Dis Colon Rectum Subsets: MEDLINE
    • Publication Information:
      Original Publication: Philadelphia. Lippincott
    • Subject Terms:
      Adenoma/*pathology ; Intestinal Neoplasms/*pathology ; Intestine, Large/*pathology; England ; Female ; Humans ; Japan ; Male ; Middle Aged ; Risk
    • Abstract:
      The malignant potential of large-intestinal adenomas varies with size, histologic type, and grade of epithelial atypia in the same way in England and in Japan. Adenomas in England have greater malignant potential than those in Japan because they grow larger and more often show a villous growth pattern. Although the adenoma--carcinoma sequence operates in the same way in the two countries it is suggested that the higher incidence of colorectal cancer in England is due to the greater prevalence as well as the greater size of English adenomas. More studies of the epidemiology and geographic pathology of large-intestinal adenomas are needed to clarify their importance as a predisposing cause of colorectal cancer in low-risk as well as high-risk areas.
    • Publication Date:
      Date Created: 19770101 Date Completed: 19770331 Latest Revision: 20190721
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/BF02587445
    • Accession Number:
      832554