Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Genomic loci of human mitogen-activated protein kinases.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Li L;Li L; Wysk M; Gonzalez FA; Davis RJ
- Source:
Oncogene [Oncogene] 1994 Feb; Vol. 9 (2), pp. 647-9.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
- Language:
English
- Additional Information
- Source:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print Cited Medium: Print ISSN: 0950-9232 (Print) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
- Publication Information:
Publication: <2002->: Basingstoke : Nature Publishing Group
Original Publication: Basingstoke, Hampshire, UK : Scientific & Medical Division, MacMillan Press, c1987-
- Subject Terms:
- Abstract:
Mitogen-activated protein (MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. Several components of the MAP kinase signal transduction pathway have been demonstrated to be oncogenically activated in malignant tumors. These include growth factor receptors, the GTP-binding protein Ras, and the protein kinase Raf. The genes that encode MAP kinases therefore represent potential targets of carcinogenic insults. Here, we report the genomic loci of three MAP kinase genes are widely distributed within the human genome: p41mapk (Erk2) at 22q11.2; p44mapk (Erk1) at 16p11.2; and p63mapk (Erk3-related) at 18q12-21.
- Grant Information:
CA58396 United States CA NCI NIH HHS; GM37845 United States GM NIGMS NIH HHS
- Gene Symbol:
p41mapk; p44mapk; p63mapk
- Accession Number:
EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 6)
EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
- Publication Date:
Date Created: 19940201 Date Completed: 19940224 Latest Revision: 20091119
- Publication Date:
20231215
- Accession Number:
8290275
No Comments.