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The metabolic response to operative stress in infants.
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- Author(s): Jones MO;Jones MO; Pierro A; Hammond P; Lloyd DA
- Source:
Journal of pediatric surgery [J Pediatr Surg] 1993 Oct; Vol. 28 (10), pp. 1258-62; discussion 1262-3.
- Publication Type:
Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: Saunders Country of Publication: United States NLM ID: 0052631 Publication Model: Print Cited Medium: Print ISSN: 0022-3468 (Print) Linking ISSN: 00223468 NLM ISO Abbreviation: J Pediatr Surg Subsets: MEDLINE
- Publication Information:
Publication: Philadelphia, PA : Saunders
Original Publication: New York.
- Subject Terms:
- Abstract:
The aim of this study was to characterize energy metabolism and substrate utilization in infants following an operation. Nineteen infants (weight 3.2 +/- 0.2 kg) who had an operation were studied. Anesthesia was standardized and operative stress score (OSS) was recorded. Five infants had a minor operation (OSS < 7), and 14 infants had a major operation (OSS > or = 7). Energy and nitrogen intake were constant during the 48-hour study period. Respiratory gas exchange was measured by indirect calorimetry preoperatively, and postoperatively for the first 12 hours continuously and at 24 hours, 48 hours, and 5 days. Urinary nitrogen excretion rate was measured for the first 48 hours following the operation. Physical activity was scored. Resting energy expenditure (REE) and nonprotein respiratory quotient (NPRQ) were calculated. REE increased postoperatively, peaking at 2 to 4 hours, and returned to baseline levels by 12 to 24 hours. Peak REE was significantly higher than baseline REE (P < .001). Substrate utilization was not altered by operation. The increase in REE was significantly greater in infants having a major operation than in infants having a minor operation (P < .05). Among infants having a major operation, the increase in REE was significantly greater in those infants more than 48 hours old, than in those infants less than 48 hours old (P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
- Accession Number:
N762921K75 (Nitrogen)
- Publication Date:
Date Created: 19931001 Date Completed: 19940124 Latest Revision: 20190710
- Publication Date:
20231215
- Accession Number:
10.1016/s0022-3468(05)80309-4
- Accession Number:
8263683
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