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Edgar Allan Poe/Sullivan's Island Library
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West Ashley Library
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Wando Mount Pleasant Library
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Village Library
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Hurd/St. Andrews Library
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Enhanced immunological response by dendritic cells in male hypogonadism.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Corrales, Juan J.; Almeida, María; Cordero, Mar; Martín-Martín, Lourdes; Méndez, Cristina; Miralles, José M.; Orfao, Alberto
- Source:
European Journal of Clinical Investigation. Nov2012, Vol. 42 Issue 11, p1205-1212. 9p. 3 Charts, 2 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Eur J Clin Invest 2012; 42 (11): 1205-1212 Abstract Background The effect of male hypogonadism on the immune response is poorly understood, even though testosterone has both immunosuppressive and anti-inflammatory effects in men. Design In this study, we compared the distribution and functional status of peripheral blood (PB) monocytes, dendritic cells (DCs) [CD16+ (monocytoid), CD33+ (myeloid) and CD33− (plasmacytoid)] and CD4+ CD25+ CD127−/lo regulatory T cells from hypogonadic men and control subjects. Immunophenotypic studies were performed both on resting and in vitro-stimulated cells. Results Overall, no significant differences were detected on the number of monocytes, DCs and CD4+ CD25+ CD127−/lo regulatory T cells between both groups of subjects. However, hypogonadic men showed slightly higher numbers of circulating CD16+ cells expressing the CD107b activation/degranulation-associated marker than controls, such differences reaching statistical significance after in vitro stimulation with CpG oligodeoxynucleotides. Interestingly, antigen-stimulated expression of CD107b on CD16+ cells inversely correlated with the serum concentrations of total testosterone ( r2 = −0·45; P = 0·01), free testosterone ( r2 = −0·48; P = 0·005), calculated free testosterone ( r2 = −0·44; P = 0·01) and bioavailable testosterone ( r2 = −0·46; P = 0·008) among all cases studied, as well as with both the LH ( r2 = −0·53, P = 0·04) and FSH ( r2 = −0·54, P = 0·04) serum levels among hypogonadic men. Conclusions These findings show an enhanced immunological response of circulating (activated) CD16+ DCs to antigen stimulation, which was inversely related to testosterone and gonadotropin serum levels. Such findings suggest a modulation by the hypothalamic-hypophyseal-gonadal axis of the immune response and may have clinical implications for hypogonadic men, as regards susceptibility to autoimmune diseases and increased responses to antigenic stimuli. [ABSTRACT FROM AUTHOR]
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