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[Alcohol-induced toxic hepatitis--a "free radical" associated disease. Lowering fatality by adjuvant antioxidant therapy].
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- Author(s): Wenzel G;Wenzel G; Kuklinski B; Rühlmann C; Ehrhardt D
- Source:
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete [Z Gesamte Inn Med] 1993 Oct; Vol. 48 (10), pp. 490-6.
- Publication Type:
Clinical Trial; Controlled Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial
- Language:
German
- Additional Information
- Transliterated Title:
Alkoholtoxische Hepatitis--eine "freie Radikale"-assoziierte Erkrankung. Letalitätssenkung durch adjuvante Antioxidantientherapie.
- Source:
Publisher: Georg Thieme Country of Publication: Germany NLM ID: 21730470R Publication Model: Print Cited Medium: Print ISSN: 0044-2542 (Print) Linking ISSN: 00442542 NLM ISO Abbreviation: Z Gesamte Inn Med Subsets: MEDLINE
- Publication Information:
Original Publication: Leipzig : Georg Thieme, [1946]-c1993.
- Subject Terms:
- Abstract:
Toxic liver diseases coincide with oxidative stress correlating positively with the seriousness of the course of disease. For the purpose of elucidating the pathogenic significance of an increased radical generation. 56 patients suffering from acute alcohol-toxic hepatitis of the clinical grade of seriousness B and C according to Child/Pugh were classified randomly into antioxidant subgroups (n = 31) and control groups (= 25). The basis therapy being identical, the patients of the antioxidant group received additionally 600 mg of D-alpha tocopherol per day, 200 micrograms of selenium and 12 mg of zinc. Due to the supplementation of antioxidants there were quicker significant changes in the concentration of bilirubin, malondialdehyde and of ammonia in the serum. In comparison with the control group the length of stay in hospital could be reduced by 6 days. In the control group the mortality rates amounted to 40% (10 of 25), in the antioxidant group to 6.5% (2 of 31). The results confirm the pathogenic significance of oxidative stress in alcohol-toxic liver disease because a distinct improvement of prognosis could be achieved by using a low-cost adjuvant antioxidant supplementation.
- Accession Number:
0 (Antioxidants)
0 (Reactive Oxygen Species)
1406-18-4 (Vitamin E)
4Y8F71G49Q (Malondialdehyde)
7664-41-7 (Ammonia)
H6241UJ22B (Selenium)
J41CSQ7QDS (Zinc)
RFM9X3LJ49 (Bilirubin)
- Publication Date:
Date Created: 19931001 Date Completed: 19940113 Latest Revision: 20221129
- Publication Date:
20250114
- Accession Number:
8256468
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