Chronic neurological sequelae to organophosphate pesticide poisoning.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: American Public Health Association Country of Publication: United States NLM ID: 1254074 Publication Model: Print Cited Medium: Print ISSN: 0090-0036 (Print) Linking ISSN: 00900036 NLM ISO Abbreviation: Am J Public Health Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : American Public Health Association
      Original Publication: New York [etc.]
    • Subject Terms:
      Organophosphorus Compounds*; Insecticides/*poisoning ; Nervous System Diseases/*chemically induced; Adolescent ; Adult ; Case-Control Studies ; Chronic Disease ; Humans ; Linear Models ; Male ; Neurologic Examination ; Neuropsychological Tests
    • Abstract:
      Objectives: This work was undertaken to determine whether there are any chronic neurological sequelae to acute organophosphate pesticide poisoning.
      Methods: California surveillance data were used in a study of neurological function among 128 men poisoned by organophosphate pesticides in California from 1982 to 1990 and 90 referents. Tests included a neurological physical examination, 5 nerve conduction tests, 2 vibrotactile sensitivity tests, 10 neurobehavioral tests, and 1 postural sway test.
      Results: After correcting for confounding, the poisoned group performed significantly worse than the referent group on two neurobehavioral tests (sustained visual attention and mood scales). When the data were restricted to men with documented cholinesterase inhibition (n = 83) or to men who had been hospitalized (n = 36), the poisoned subjects also showed significantly worse vibrotactile sensitivity of finger and toe. Significant trends of increased impairment were found with increased days of disability on a wide spectrum of tests of both central and peripheral nerve function.
      Conclusions: While these findings are limited by low response rates and by small sample sizes for specific pesticides, this study was based on a large surveillance database and is the largest study to date of the chronic effects of organophosphate pesticide poisoning. The evidence of some long-term effects of poisoning is consistent with two prior studies.
    • References:
      Arch Toxicol. 1986 Oct;59(3):176-9. (PMID: 2434058)
      Am J Public Health. 1987 Feb;77(2):191-4. (PMID: 3799859)
      Neurotoxicol Teratol. 1990 Jan-Feb;12(1):1-6. (PMID: 2314356)
      Lancet. 1991 Jul 27;338(8761):223-7. (PMID: 1676786)
      Am J Emerg Med. 1991 Sep;9(5):461-509. (PMID: 1863304)
      Arch Environ Health. 1989 Jan-Feb;44(1):34-9. (PMID: 2916853)
      Arch Environ Health. 1990 May-Jun;45(3):148-54. (PMID: 2167042)
      Am J Ind Med. 1993 Jun;23(6):845-58. (PMID: 8392292)
      Arch Environ Health. 1988 Jan-Feb;43(1):38-45. (PMID: 3355242)
    • Accession Number:
      0 (Insecticides)
      0 (Organophosphorus Compounds)
    • Publication Date:
      Date Created: 19940501 Date Completed: 19940603 Latest Revision: 20190514
    • Publication Date:
      20231215
    • Accession Number:
      PMC1615045
    • Accession Number:
      10.2105/ajph.84.5.731
    • Accession Number:
      8179040