Melanotic neuroectodermal tumor of infancy in the skull associated with high serum levels of catecholamine. Case report.

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  • Additional Information
    • Source:
      Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 0253357 Publication Model: Print Cited Medium: Print ISSN: 0022-3085 (Print) Linking ISSN: 00223085 NLM ISO Abbreviation: J Neurosurg Subsets: MEDLINE
    • Publication Information:
      Publication: Charlottesville, VA : American Association of Neurological Surgeons
      Original Publication: Chicago [etc.]
    • Subject Terms:
      Catecholamines/*blood ; Neuroectodermal Tumor, Melanotic/*blood ; Skull Neoplasms/*blood; Humans ; Infant ; Male ; Neuroectodermal Tumor, Melanotic/pathology ; Neuroectodermal Tumor, Melanotic/surgery ; Skull Neoplasms/pathology ; Skull Neoplasms/surgery
    • Abstract:
      The case of a 5-month-old boy with a left retromastoid melanotic neuroectodermal tumor of infancy is presented. The tumor extended from the subcutaneous tissue of the occiput to the cerebellar hemisphere. Histologically, the epidural part of the tumor was composed of undifferentiated neuroblasts, dense connective tissue, and glandular structures lined by melanin-containing cuboidal cells, whereas the subdural part contained differentiated neuroblasts and melanin-containing cells. The preoperative high serum levels of adrenaline, noradrenaline, vanillylmandelic acid, and neuron-specific enolase returned to normal after two operations and two cycles of chemotherapy; however, the dopamine level was mildly elevated. These data and immunohistochemical and ultrastructural findings strongly suggest that melanotic neuroectodermal tumor of infancy is derived from the neural crest.
    • Comments:
      Comment in: J Neurosurg. 1995 May;82(5):910-1. (PMID: 7714622)
    • Accession Number:
      0 (Catecholamines)
    • Publication Date:
      Date Created: 19940501 Date Completed: 19940601 Latest Revision: 20041117
    • Publication Date:
      20221213
    • Accession Number:
      10.3171/jns.1994.80.5.0919
    • Accession Number:
      8169635