[The functional and morphochemical characteristics of the hippocampal neurons during the formation of trace processes in old rabbits].

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  • Author(s): Kopytova FV; Gershteĭn LM; Dobrynina MT; Krivitskaia GN
  • Source:
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 1993 Nov-Dec; Vol. 43 (6), pp. 1225-33.
  • Publication Type:
    Comparative Study; English Abstract; Journal Article
  • Language:
    Russian
  • Additional Information
    • Transliterated Title:
      Funktsional'nye i morfokhimicheskie osobennosti neĭronov gippokampa pri formirovanii sledovykh protsessov u krolikov starogo vozrasta.
    • Source:
      Publisher: Izd-Vo Akademiia Nauk Ssr Country of Publication: Russia (Federation) NLM ID: 9421551 Publication Model: Print Cited Medium: Print ISSN: 0044-4677 (Print) Linking ISSN: 00444677 NLM ISO Abbreviation: Zh Vyssh Nerv Deiat Im I P Pavlova Subsets: MEDLINE
    • Publication Information:
      Publication: Moscow : Izd-Vo Akademiia Nauk Ssr
      Original Publication: Moscow, Izd-vo Akademiia nauk SSR.
    • Subject Terms:
      Aging/*physiology ; Higher Nervous Activity/*physiology ; Hippocampus/*physiology ; Neurons/*physiology; Animals ; Conditioning, Classical/physiology ; Electric Stimulation ; Hippocampus/cytology ; Histocytochemistry ; Neurons/cytology ; Periodicity ; Rabbits ; Wakefulness/physiology
    • Abstract:
      Trace rhythmic activity of dorsal hippocampal neurons were studied after the long-lasting (10-20 min) rhythmic (0.5-2 Hz) electrocutaneous stimulation of the forelimb in alert young (5-7 months), middle-aged (54-65 months), and very old (66-84 months) rabbits. During aging the number of spontaneously active neurons was shown to be significantly decreased, the proportion of slowly firing neurons to be increased, the interspike intervals and intervals between spike groups to lengthen, and the number of spikes per a group to be reduced. Spectral analysis of neuronal firing rate revealed that ability to reproduce the rhythm of the previous stimulation declined with age. No appropriate rhythms were found in hippocampal neurons of the old animals. Morphological and cytochemical analysis of the hippocampal neurons revealed changes in nuclear-cytoplasmic relations and also a fall of protein synthesis in the neurons of the old animals. The observed deteriorations may explain the impairment of trace rhythmic activity in hippocampal cells with age.
    • Publication Date:
      Date Created: 19931101 Date Completed: 19940415 Latest Revision: 20061115
    • Publication Date:
      20231215
    • Accession Number:
      8135066