Differential effects of infused nutrients on 2-deoxy-D-glucose- and 2-mercaptoacetate-induced feeding.

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  • Author(s): Singer LK;Singer LK; Ritter S
  • Source:
    Physiology & behavior [Physiol Behav] 1994 Jul; Vol. 56 (1), pp. 193-6.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print Cited Medium: Print ISSN: 0031-9384 (Print) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
    • Publication Information:
      Publication: New York NY : Elsevier Science
      Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
    • Subject Terms:
      Deoxyglucose/*pharmacology ; Fat Emulsions, Intravenous/*pharmacology ; Feeding Behavior/*drug effects ; Fructose/*pharmacology ; Glucose Solution, Hypertonic/*pharmacology ; Receptors, Cell Surface/*drug effects ; Satiety Response/*drug effects ; Thioglycolates/*pharmacology; Animals ; Brain/drug effects ; Energy Intake/drug effects ; Male ; Rats ; Rats, Sprague-Dawley
    • Abstract:
      We examined the effects of glucose, lipid, or fructose infusion on 2-deoxy-D-glucose (2DG)- and 2-mercaptoacetate (MA)-induced feeding. Rats with chronic intra-atrial catheters were infused for 15 min with one of the above nutrients and then injected with 2DG or MA. The nutrient infusion continued for the next 2 h and food intake was simultaneously measured. For control conditions, equitonic saline was infused, and 2DG, MA, or saline was injected. We found that glucose was the only nutrient source capable of significantly reducing 2DG-induced feeding. Equicaloric infusions of lipid or fructose did not significantly reduce 2DG-induced feeding. However, feeding induced by MA was similarly and significantly reduced by glucose, lipid, and fructose. These results suggest that 2DG-induced feeding is mediated by receptor cells that are selectively responsive to glucose availability, and MA-induced feeding is mediated by receptor cells that are responsive to a wider range of metabolic fuels.
    • Accession Number:
      0 (Fat Emulsions, Intravenous)
      0 (Glucose Solution, Hypertonic)
      0 (Receptors, Cell Surface)
      0 (Thioglycolates)
      0 (glucose receptor)
      30237-26-4 (Fructose)
      7857H94KHM (2-mercaptoacetate)
      9G2MP84A8W (Deoxyglucose)
    • Publication Date:
      Date Created: 19940701 Date Completed: 19941011 Latest Revision: 20190712
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/0031-9384(94)90279-8
    • Accession Number:
      8084901