[Effectiveness of pathogenetic treatment of arterial obliterative diseases of the extremities].

Vozmozhnosti patogeneticheskogo lecheniia obliteriruiushchikh zabolevaniĭ arteriĭ konechnosteĭ.

Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 0412765 Publication Model: Print Cited Medium: Print ISSN: 0023-1207 (Print) Linking ISSN: 00231207 NLM ISO Abbreviation: Khirurgiia (Mosk) Subsets: MEDLINE

Publication: <2003->: Moskva : Media Sfera
Original Publication: Moskva, Meditsina [etc.]

Amine Oxidase (Copper-Containing)*; Arteriosclerosis Obliterans/*drug therapy ; Endarteritis/*drug therapy ; Testosterone/*therapeutic use; Adult ; Aged ; Arm/blood supply ; Arteriosclerosis Obliterans/enzymology ; Endarteritis/enzymology ; Hemodynamics/drug effects ; Humans ; Injections, Intramuscular ; Leg/blood supply ; Male ; Middle Aged ; Oxidoreductases Acting on CH-NH Group Donors/drug effects ; Severity of Illness Index ; Testosterone/pharmacology

The authors studied the activity of blood serum amine oxidase in patients with atherosclerosis obliterans and endarteritis obliterans. It was found that amine oxidase activity exceeded the normal value. 2.6 times in patients with stage 1-2 atherosclerosis obliterans and was reduced by more than 12 times in patients with stage 3-4 of the disease. The activity of the enzyme was absent in patients with endarteritis obliterans, whatever the stage of limb ischemia. On the basis of the obtained facts, the authors voice a new opinion on the nature of hypercatecholaminemia in obliterative diseases and suggest a new trend in the treatment of chronic ischemia of the limbs-activation of the processes of catabolism of vasoconstrictive biogenic amines.

3XMK78S47O (Testosterone)
EC 1.4.3.21 (Amine Oxidase (Copper-Containing))
EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors)

Date Created: 19930201 Date Completed: 19941013 Latest Revision: 20131121

20231215

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