Mycobacterium avium infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens.

Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104 (Print) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE

Publication: 2022- : Oxford : Oxford University Press
Original Publication: Oxford : Blackwell Scientific Publications

HIV-1*/immunology ; HIV-1*/isolation & purification; AIDS-Related Opportunistic Infections/*complications ; AIDS-Related Opportunistic Infections/*immunology ; Monokines/*metabolism ; Mycobacterium avium-intracellulare Infection/*complications ; Mycobacterium avium-intracellulare Infection/*immunology; AIDS-Related Opportunistic Infections/microbiology ; Cytokines/blood ; Cytokines/metabolism ; HIV Antigens/immunology ; HIV Core Protein p24/blood ; Humans ; Immunity, Cellular ; In Vitro Techniques ; Leukocytes, Mononuclear/immunology ; Lymphocyte Activation ; Mycobacterium avium-intracellulare Infection/microbiology ; beta 2-Microglobulin/metabolism

The complex interaction between HIV-1 infection and Mycobacterium avium was studied. Viral burden was assessed, as well as immune response to HIV-1 in the context of Myco. avium infections. We also examined serum cytokine levels and cytokine release by blood mononuclear cells in HIV-1-infected subjects, infected or not with Myco. avium. Undetectable serum levels of IL-1, tumour necrosis factor-alpha (TNF-alpha) and IL-6 were found in normal controls and in groups I, II and III of HIV-1-infected subjects. Moderate levels of TNF-alpha, IL-1 and IL-6 were found in the sera of group IV patients. When group IV was subdivided into subjects with and without Myco. avium infections, subjects with Myco, avium infections were shown to have higher serum levels of TNF-alpha, IL-1 beta and IL-6 than those with other infections. Blood mononuclear cells from controls and HIV subjects were stimulated with bacterial lipopolysaccharide, and cytokine levels assessed. Cells from group II patients were shown to secrete normal levels of TNF-alpha and IL-6, and lower levels of IL-1 beta; group III subjects released higher levels of IL-6. Patients in group IV had blood cells that released elevated levels of IL-6 and TNF-alpha, and lower levels of IL-1 beta. Group IV subjects with Myco. avium infections had blood cells that released higher levels of TNF-alpha, IL-6 and IL-1 than group IV subjects with other infections. Assessment of viral burden in cells of HIV-1-infected subjects revealed that Myco. avium-infected subjects had a higher level of virus burden and a lower level of lymphoproliferative response to an inactivated gp120-depleted HIV-1 antigen than AIDS subjects with other infections. These data suggest that Myco. avium infections in HIV-1-infected subjects hasten the progression of viral disease, enhance cytokine release and contribute to the anergy to viral antigens.

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0 (Cytokines)
0 (HIV Antigens)
0 (HIV Core Protein p24)
0 (Monokines)
0 (beta 2-Microglobulin)

Date Created: 19940701 Date Completed: 19940818 Latest Revision: 20190512

20231215

PMC1534796

10.1111/j.1365-2249.1994.tb06582.x

8033423