Pressure transmission across the respiratory system at raised lung volumes in infants.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Turner DJ;Turner DJ; Lanteri CJ; LeSouef PN; Sly PD
  • Source:
    Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 1994 Aug; Vol. 77 (2), pp. 1015-20.
  • Publication Type:
    Clinical Trial; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print Cited Medium: Print ISSN: 8750-7587 (Print) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bethesda, MD : American Physiological Society, c1985-
    • Subject Terms:
      Forced Expiratory Volume*/physiology; Lung/*physiopathology ; Respiratory System/*physiopathology; Cystic Fibrosis/physiopathology ; Esophagus/physiology ; Humans ; Infant ; Pressure ; Residual Volume/physiology ; Respiratory Syncytial Virus Infections/physiopathology ; Respiratory Syncytial Virus, Human ; Thorax/physiopathology
    • Abstract:
      Forced expiratory flow-volume (FEFV) curves can be generated from end-tidal inspiration in infants with use of an inflatable jacket. We have developed a technique to raise lung volume in the infant before generation of FEFV curves. Measurements of pressure transmission to the airway opening by use of static maneuvers have shown no change with increasing lung volume above end-tidal inspiration. The aim of this study was to determine, under dynamic conditions (i.e., during rapid thoracic compression), whether the efficiency of pressure transmission across the chest wall is altered by raising lung volume above the tidal range. Dynamic pressure transmission (Ptx,dyn) was measured in five infants (age 6-17 mo). Jacket pressure (Pj), esophageal pressure, and volume were measured throughout passive and FEFV curves at lung volumes set by 10, 15, and 20 cmH2O preset pressure. The group mean Ptx,dyn was 37 +/- 6% (SE) of Pj at end-tidal inspiration, and no change was seen with further increases in lung volume. However, a mean decrease in Ptx,dyn of 42% was evident throughout the tidal volume range (i.e., from end-tidal inspiration to end expiration). Isovolume static pressure transmission (Ptx,st) was measured in three of the five infants by inflation of the jacket in a stepwise manner with the airway closed. Measurements were made at end-tidal inspiration and lung volumes at 10, 15, and 20 cmH2O preset pressure. Resulting changes in Pj, esophageal pressure, and airway opening pressure were compared using linear regressions to determine Ptx,st.(ABSTRACT TRUNCATED AT 250 WORDS)
    • Publication Date:
      Date Created: 19940801 Date Completed: 19950120 Latest Revision: 20171213
    • Publication Date:
      20240829
    • Accession Number:
      10.1152/jappl.1994.77.2.1015
    • Accession Number:
      8002486