[Habituation and effects of protein synthesis blockers on neuronal activity in the cerebral sensorimotor cortex in rabbits].

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  • Additional Information
    • Transliterated Title:
      Habituacija i efekti blokatora sinteze proteina na neuronsku aktivnost senzomotorne kore mozga kunića.
    • Source:
      Publisher: Društvo lekara Vojvodine Country of Publication: Serbia NLM ID: 2985249R Publication Model: Print Cited Medium: Print ISSN: 0025-8105 (Print) Linking ISSN: 00258105 NLM ISO Abbreviation: Med Pregl Subsets: MEDLINE
    • Publication Information:
      Original Publication: Novi Sad : Društvo lekara Vojvodine
    • Subject Terms:
      Habituation, Psychophysiologic*/drug effects; Motor Cortex/*drug effects ; Protein Synthesis Inhibitors/*pharmacology ; Somatosensory Cortex/*drug effects; Acetylcholine/pharmacology ; Action Potentials ; Animals ; Cycloheximide/pharmacology ; Dactinomycin/pharmacology ; Female ; Male ; Motor Cortex/physiology ; Neurons/drug effects ; Neurons/physiology ; Rabbits ; Somatosensory Cortex/physiology
    • Abstract:
      The investigation of brain functions has been for many years an exciting and at the same time a very complex and enigmatic domain of research. In our experiments we followed the occurrence of habituation, a simple form of learning, during a peripheral light stimulation, in sensorimotor cortex neurons of rabbits. In the majority of the mature neurons habituation occurred with repeated light stimulations with same features, while in immature rabbits it was less frequently observed and was slower. Since in basic patterns of habituation and learning, cell protein plays a significant role, we followed the effects of protein synthesis blockers in the process of training and electrogenesis. Microiontophoretic application of actinomycin D and cyclohexamide compromised the occurrence of habituation in high number of registered neurons, while the application of a neurotransmitter, acetyl choline, promoted habituation in the sensorimotor brain cortex neurons of immature experimental animals.
    • Accession Number:
      0 (Protein Synthesis Inhibitors)
      1CC1JFE158 (Dactinomycin)
      98600C0908 (Cycloheximide)
      N9YNS0M02X (Acetylcholine)
    • Publication Date:
      Date Created: 19930101 Date Completed: 19941128 Latest Revision: 20131121
    • Publication Date:
      20240829
    • Accession Number:
      7968820