Gallbladder ejection fraction. Nondiagnostic for sphincter of Oddi dysfunction in patients with intact gallbladders.

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  • Additional Information
    • Source:
      Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print Cited Medium: Print ISSN: 0363-9762 (Print) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Philadelphia, Lippincott.
    • Subject Terms:
      Gallbladder/*diagnostic imaging ; Gallbladder Emptying/*physiology ; Sphincter of Oddi/*diagnostic imaging; Abdominal Pain/etiology ; Adult ; Common Bile Duct Diseases/diagnostic imaging ; Double-Blind Method ; Female ; Humans ; Imino Acids ; Male ; Organotechnetium Compounds ; Prospective Studies ; Radionuclide Imaging ; Regression Analysis ; Sensitivity and Specificity ; Sincalide ; Sphincter of Oddi/physiopathology ; Technetium Tc 99m Disofenin
    • Abstract:
      Thirty consecutive patients with intact gallbladders and biliary pain were evaluated to determine whether gallbladder ejection fraction could identify sphincter of Oddi dysfunction. The mean gallbladder ejection fraction was 45% in patients with abdominal pain and 72% in normal controls. Gallbladder ejection fractions were then correlated with endoscopically measured sphincter of Oddi pressures in patients with abdominal pain. The mean gallbladder ejection fraction was 41% in 7 patients with elevated sphincter pressures and 46% in 23 patients with normal pressures (P = NS). Thirty-six percent of patients with elevated pressures and 33% of patients with normal pressures had abnormal gallbladder ejection fractions. Gallbladder ejection fraction had a sensitivity of 33%, a specificity of 63%, and a positive predictive value of 25% for detection of elevated pressures. Regression analysis revealed a poor correlation between sphincter pressure and gallbladder ejection fraction (r2 = 0.02). These findings suggest that gallbladder ejection fraction cannot be used to diagnose sphincter of Oddi dysfunction in patients before they undergo cholecystectomy.
    • Accession Number:
      0 (Imino Acids)
      0 (Organotechnetium Compounds)
      M03GIQ7Z6P (Sincalide)
      QTJ2VIW97T (Technetium Tc 99m Disofenin)
    • Publication Date:
      Date Created: 19940801 Date Completed: 19941215 Latest Revision: 20161123
    • Publication Date:
      20231215
    • Accession Number:
      7955753