Blood volume redistribution from a passive elastic permeable microcirculation due to hypovolemia.

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  • Author(s): LaForte AJ;LaForte AJ; Lee LP; Rich GF; Skalak TC; Lee JS
  • Source:
    The American journal of physiology [Am J Physiol] 1994 Jun; Vol. 266 (6 Pt 2), pp. H2268-78.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 0370511 Publication Model: Print Cited Medium: Print ISSN: 0002-9513 (Print) Linking ISSN: 00029513 NLM ISO Abbreviation: Am J Physiol Subsets: MEDLINE
    • Publication Information:
      Publication: Bethesda, MD : American Physiological Society
      Original Publication: Washington [etc.] American Physiological Society.
    • Subject Terms:
      Blood Volume*; Blood Circulation/*physiology ; Hemorrhage/*physiopathology; Animals ; Blood Pressure ; Cardiac Output ; Elasticity ; Heart Rate ; Hemodynamics ; Hexamethonium ; Hexamethonium Compounds/pharmacology ; Male ; Microcirculation/physiology ; Models, Cardiovascular ; Permeability ; Rabbits
    • Abstract:
      We measured the variations in blood and plasma density for a cyclic hemorrhage protocol in conscious rabbits to calculate delta Vf [the volume of fluid restituted into the circulation from the time the blood volume was at its control to that after the hemorrhage of a blood volume (delta V)] and delta Vs (the volume shift from micro- to macrocirculation over the same time interval). We found that delta Vf is 7% of delta V and delta Vs 60% of delta V. They combine to reduce the effect of hemorrhage on macrovascular volume by 67% of delta V. Based on a two-resistor circulation model, the change in microcirculatory pressure (delta Pmic) from control to hemorrhage was estimated from the measured cardiac outputs and arterial and venous pressures. The computations indicate that delta Vs (or delta Vf) is linearly related to delta Pmic. With one relation fitting all data of rabbits that were conscious, infused with hexamethonium, and anesthetized with pentobarbital sodium, we concluded that the two short-term volume redistributions are not direct neural control or local regulation, but the response of a passive, permeable microcirculation to delta Pmic. From the linear relations, we obtained 0.88 ml.mmHg-1.kg-1 as the compliance of the rabbit microcirculation and 0.21 ml.min-1.mmHg-1.kg-1 as its filtration coefficient.
    • Grant Information:
      HL-40565 United States HL NHLBI NIH HHS
    • Accession Number:
      0 (Hexamethonium Compounds)
      3C9PSP36Z2 (Hexamethonium)
    • Publication Date:
      Date Created: 19940601 Date Completed: 19940802 Latest Revision: 20171213
    • Publication Date:
      20231215
    • Accession Number:
      10.1152/ajpheart.1994.266.6.H2268
    • Accession Number:
      7912898