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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
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Telomere length in circulating serum DNA as a novel non-invasive biomarker for cirrhosis: a nested case-control analysis.
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- Author(s): Wan, Shaogui; Hann, Hie-Won; Myers, Ronald E.; Fu, Xiaoying; Hann, Richard S.; Kim, Su H.; Tang, Heng; Xing, Jinliang; Yang, Hushan
- Source:
Liver International; Sep2012, Vol. 32 Issue 8, p1233-1241, 9p, 4 Charts, 1 Graph- Subject Terms:
- Source:
- Additional Information
- Abstract: Background & Aims Previous studies have indicated that telomere length is associated with altered risk of various tumours including hepatitis B virus ( HBV)-related hepatocellular carcinoma. However, the association between telomere length and the risk of cirrhosis has not been reported. Methods In this nested case-control study, we used real-time quantitative PCR to determine the relative telomere length ( RTL) in serum DNA samples from 100 HBV-related cirrhosis cases and 100 frequency-matched HBV controls, and evaluated the associations between RTL and cirrhosis risk by logistic regression analyses. Results We found that cirrhotic cases had a significantly longer RTL (median, 0.36; range, 0.08-1.87) than non-cirrhotic controls (median, 0.20; range, 0.05-1.11) ( P < 0.0001). Compared with subjects with short RTL, those with long RTL had a significantly increased cirrhosis risk [odds ratio, 2.76, 95% confidence interval, 1.50-5.10; P = 0.001]. Quartile analysis further indicated a dose-response effect for this association. Compared with patients with the lowest quartile of RTL, the cirrhosis risk for those with the second, third and highest quartile of RTL was 2.68 (0.91-7.87, P = 0.073), 3.37 (1.32-10.54, P = 0.013) and 6.64 (2.41-18.32, P < 0.0001) respectively ( P
trend <0.0001). Moreover, the area under the receiver operating characteristic curve increased from 0.60 (epidemiological variables) to 0.72 (epidemiological variables plus RTL), with statistically significant difference assessed by bootstrap analysis. Conclusions Our study presents the first epidemiological evidence that RTL in serum DNA could potentially be used as a simple, inexpensive and non-invasive marker of cirrhosis risk, a finding that warrants further investigations in independent retrospective and prospective populations. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Liver International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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