High progesterone levels adversely affect embryo quality and pregnancy rates in in vitro fertilization and oocyte donation programs.

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  • Additional Information
    • Source:
      Publisher: Elsevier for the American Society for Reproductive Medicine Country of Publication: United States NLM ID: 0372772 Publication Model: Print Cited Medium: Print ISSN: 0015-0282 (Print) Linking ISSN: 00150282 NLM ISO Abbreviation: Fertil Steril Subsets: MEDLINE
    • Publication Information:
      Publication: New York. NY : Elsevier for the American Society for Reproductive Medicine
      Original Publication: New York, Hoeber.
    • Subject Terms:
      Fertilization in Vitro* ; Oocyte Donation* ; Pregnancy*; Embryo, Mammalian/*physiology ; Progesterone/*blood; Adult ; Female ; Humans ; Regression Analysis ; Retrospective Studies
    • Abstract:
      Objective: To assess the effect of P levels on oocyte and embryo quality and pregnancy rates (PRs) in IVF and oocyte donation.
      Design: Retrospective analysis of PRs in ovum donors and their recipients with regard to P levels on day of hCG administration.
      Setting: In Vitro Fertilization Units, oocyte donation programs.
      Patients: In vitro fertilization patients who agreed to donate oocytes were treated by hMG alone (53 cycles) or in combination with a GnRH analog (122 cycles).
      Interventions: Uterine preparation in oocyte recipients consisted of 6 mg/d E2 valerate. Progesterone (100 mg/d) was added when oocytes became available. Hormonal treatment was continued until 12 weeks of gestation.
      Results: Using a series of Fisher's Exact Tests, a critical threshold for P was identified at 1.9 ng/mL (conversion factor to SI units, 3.185). With elevated P levels (> 1.9 ng/mL), lower PRs were noted for the donors (7.1% versus 17%), as well for the recipients (8.3% versus 26.7%).
      Conclusions: Exposure to elevated P levels resulted in lower PRs for the donors and significantly lower PRs in the recipients. Because the endometria in the recipients were prepared uniformly, we conclude that this is the result of detrimental effects of P on oocyte or embryo quality.
    • Accession Number:
      4G7DS2Q64Y (Progesterone)
    • Publication Date:
      Date Created: 19950701 Date Completed: 19950725 Latest Revision: 20170920
    • Publication Date:
      20231215
    • Accession Number:
      7789547