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Comparación de la respuesta inmunológica frente a cepas de S. pneumoniae, evaluada por hemaglutinación, en niños inmunizados con vacuna neumocócica heptavalente (dos primovacunaciones con o sin refuerzo). (Spanish)
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- Author(s): Silva-Rosales, Norma Angélica; Tene, Carlos Enrique; Cervantes-Kardasch, Víctor Hugo; Del-Toro, Mario
- Source:
Boletín Médico del Hospital Infantil de México; Mar/Apr2012, Vol. 69 Issue 2, p97-103, 7p, 2 Charts- Subject Terms:
- Source:
- Additional Information
- Alternate Title: Comparison of the immune response against strains of S. pneumoniae, assessed by hemagglutination, in children immunized with heptavalent conjugated pneumococcal vaccine (two primary vaccinations with or without reinforcement). (English)
- Abstract: Background. Different patterns of heptavalent conjugated pneumococcal vaccine immunization have proven effective. Although three and four doses are recommended, there are still children who are administered schemes of two primary vaccination doses without reinforcement. The aim of this study was to compare the immune response against S. pneumoniae in children (group A and group B) submitted to different immunization schemes (two primary vaccination doses with or without reinforcement). Methods. We conducted an observational, cross-sectional study comparing the immune response between group A and group B, analyzing the weak immune response with positive hemagglutination dilution ≤1:2. Odds ratio (OR) and Fisher's exact test were used. Results. There were no clinical differences between group A (n = 14) and group B (n = 15). There was a higher proportion of weak immune response in group A (57% vs. 13%, OR 8.7 (95% CI 1.3--53.8, p = 0.017). Conclusions. Weak immune response against S. pneumoniae is higher in schemes primed with two doses of heptavalent conjugated pneu- mococcal vaccine without reinforcement than using the two-dose schedule + a booster of heptavalent conjugated pneumococcal vaccine. [ABSTRACT FROM AUTHOR]
- Abstract: Introducción. Diferentes esquemas de inmunización con la vacuna antineumocócica heptavalente han probado su eficacia. Aunque se recomiendan pautas vacunales de dos o tres primovacunaciones con su respectivo refuerzo adicional, aún hay niños con primovacu- naciones sin refuerzo. El objetivo de este trabajo fue comparar la respuesta inmunológica contra S. pneumoniae en niños bajo distintos esquemas de inmunización (dos o tres dosis) con vacuna antineumocócica heptavalente. Métodos. Se realizó un estudio observacional y transversal para comparar la respuesta inmunológica entre los grupos A (dos primovacu- naciones sin refuerzo) y B (dos primovacunaciones con refuerzo). Se analizó la respuesta inmunológica escasa por medio de hemagluti- nación positiva (dilución ≤ 1:2). Se calculó la razón de momios (OR) y se aplicó la prueba exacta de Fisher. Resultados. No se encontraron diferencias clínicas entre los grupos A (n = 14) y B (n = 15). Hubo mayor proporción de respuesta inmu- nológica escasa en el grupo A [57% vs 13%; OR 8.7 (IC 95% 1.3--53.8); p = 0.017]. Conclusiones. La respuesta inmunológica escasa contra S. pneumoniae es mayor en los esquemas de dos dosis de primovacunación sin refuerzo que cuando se utilizan dos dosis de primovacunación con refuerzo. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Boletín Médico del Hospital Infantil de México is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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