Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Print ISSN: 0028-0836 (Print) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
    • Publication Information:
      Publication: Basingstoke : Nature Publishing Group
      Original Publication: London, Macmillan Journals ltd.
    • Subject Terms:
      Chorionic Gonadotropin/*therapeutic use ; Sarcoma, Kaposi/*therapy; Acquired Immunodeficiency Syndrome/complications ; Adult ; Animals ; Apoptosis ; Female ; Humans ; Immunocompromised Host ; Male ; Mice ; Mice, Nude ; Pregnancy ; Sarcoma, Kaposi/complications ; Sarcoma, Kaposi/immunology ; Sarcoma, Kaposi/secondary ; Tumor Cells, Cultured
    • Abstract:
      Kaposi's sarcoma (KS) occurs more often in men than in women and HIV-1-associated KS has a high occurrence in homosexual men (over 30%). Most cultures of KS tumours yield cells with properties of hyperplastic (not malignant) endothelial cells under the control of several cytokines. The role of HIV-1 may be in promoting high levels of some cytokines and providing stimulation to angiogenesis by the HIV-1 Tat protein, which synergizes with basic fibroblast growth factor in promoting these effects. Here we describe an immortalized AIDS-KS cell line (KS Y-1) and show that these cells produce malignant metastatic tumours in nude mice and are killed in vitro and in vivo (apparently by apoptosis) by a pregnancy hormone, the beta-chain of human chorionic gonadotropin. Similarly, chorionic gonadotropin kills KS SLK, cells from another neoplastic cell line (established from a non-HIV-associated KS), as well as the hyperplastic KS cells from clinical specimens grown in short-term culture, but does not kill normal endothelial cells. These results provide evidence that KS can evolve into a malignancy and have implications for the hormonal treatment of this tumour.
    • Comments:
      Erratum in: Nature 1995 Aug 3;376(6539):447.
      Comment in: Nature. 1995 Sep 7;377(6544):21; author reply 22. (PMID: 7659154)
      Comment in: Nature. 1995 Sep 7;377(6544):21-2. (PMID: 7659155)
    • Accession Number:
      0 (Chorionic Gonadotropin)
    • Publication Date:
      Date Created: 19950504 Date Completed: 19950525 Latest Revision: 20041117
    • Publication Date:
      20221213
    • Accession Number:
      10.1038/375064a0
    • Accession Number:
      7723844