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Helicobacter pylori gastritis therapy with omeprazole and clarithromycin increases serum carbamazepine levels.
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- Author(s): Metz DC;Metz DC; Getz HD
- Source:
Digestive diseases and sciences [Dig Dis Sci] 1995 Apr; Vol. 40 (4), pp. 912-5.
- Publication Type:
Case Reports; Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print Cited Medium: Print ISSN: 0163-2116 (Print) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE
- Publication Information:
Publication: 2005- : New York, NY : Springer Science + Business Media
Original Publication: New York, Plenum Pub. Corp.
- Subject Terms:
- Abstract:
An antibiotic combination that includes a proton pump inhibitor such as omeprazole and an antibiotic such as clarithromycin is likely to become the new standard regimen for treatment of Helicobacter pylori gastritis because this combination is extremely effective and very well tolerated. The current report highlights a potentially significant pharmakokinetic drug interaction between clarithromycin and carbamazepine in two patients with long-standing epilepsy who were given such therapy for Helicobacter pylori gastritis. In both cases, clarithromycin therapy was temporally related to an increase in serum carbamazepine levels, which returned to the therapeutic range following cessation of clarithromycin therapy. The potential implications of this newly recognized drug interaction are discussed.
- Comments:
Comment in: Dig Dis Sci. 1996 Mar;41(3):519-20. (PMID: 8617126)
- References:
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- Accession Number:
33CM23913M (Carbamazepine)
F8VB5M810T (Tetracycline)
H1250JIK0A (Clarithromycin)
KG60484QX9 (Omeprazole)
- Publication Date:
Date Created: 19950401 Date Completed: 19950524 Latest Revision: 20190721
- Publication Date:
20221213
- Accession Number:
10.1007/BF02064999
- Accession Number:
7720489
No Comments.