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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
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Otranto Road Library
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McClellanville Library
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John's Island Library
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα
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- Author(s): Shin, Youseung1; Noel, Romain1; Banerjee, Subhashis1; Kojetin, Douglas1; Song, Xinyi1; He, Yuanjun1; Lin, Li1; Cameron, Michael D.1; Burris, Thomas P.1; Kamenecka, Theodore M.
- Source:
Bioorganic & Medicinal Chemistry Letters. Jul2012, Vol. 22 Issue 13, p4413-4417. 5p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Abstract: The structure–activity relationship study of a small molecule Rev-erbα agonist is reported. The potency and efficacy of the agonists in a cell-based assay were optimized as compared to the initial lead. Modest mouse pharmacokinetics coupled with an improved in vitro profile make 12e a suitable in vivo probe to interrogate the functions of Rev-erbα in animal models of disease. [Copyright &y& Elsevier]
- Abstract: Copyright of Bioorganic & Medicinal Chemistry Letters is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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