RNA processing in prokaryotic cells.

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  • Author(s): Apirion D;Apirion D; Miczak A
  • Source:
    BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 1993 Feb; Vol. 15 (2), pp. 113-20.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 8510851 Publication Model: Print Cited Medium: Print ISSN: 0265-9247 (Print) Linking ISSN: 02659247 NLM ISO Abbreviation: Bioessays Subsets: MEDLINE
    • Publication Information:
      Publication: <2005->: Hoboken, N.J. : Wiley
      Original Publication: Cambridge, UK : Published for the ICSU Press by Cambridge University Press, c1984-
    • Subject Terms:
      RNA Processing, Post-Transcriptional*; Prokaryotic Cells/*metabolism ; RNA, Bacterial/*metabolism; Bacterial Proteins/metabolism ; Base Sequence ; Escherichia coli/metabolism ; Introns ; Molecular Sequence Data ; RNA, Catalytic/metabolism ; RNA, Ribosomal/metabolism ; RNA, Transfer/metabolism ; Ribonucleases/metabolism
    • Abstract:
      RNA processing in Escherichia coli and some of its phages is reviewed here, with primary emphasis on rRNA and tRNA processing. Three enzymes, RNase III, RNase E and RNase P are responsible for most of the primary endonucleolytic RNA processing events. The first two are proteins, while RNase P is a ribozyme. These three enzymes have unique functions and in their absence, the cleavage events they catalyze are not performed. On the other hand a relatively large number of exonucleases participate in the trimming of the 3' ends of tRNA precursor molecules and they can substitute for each other. Primary processing is the first event that happens to the nascent RNA molecule, while in secondary RNA processing, the substrate is a product of a primary processing event. Although most RNA processing occurs in RNP particles, it seems that only in secondary RNA processing is the RNP particle required for the reaction. Bacteria and especially bacteriophages contain self-splicing introns which in cases were probably acquired from other species.
    • Number of References:
      52
    • Accession Number:
      0 (Bacterial Proteins)
      0 (RNA, Bacterial)
      0 (RNA, Catalytic)
      0 (RNA, Ribosomal)
      9014-25-9 (RNA, Transfer)
      EC 3.1.- (Ribonucleases)
    • Publication Date:
      Date Created: 19930201 Date Completed: 19930513 Latest Revision: 20061115
    • Publication Date:
      20240829
    • Accession Number:
      10.1002/bies.950150207
    • Accession Number:
      7682412