[Efficacy of treatment with frequent and low-dose epirubicin in two cases of pulmonary metastases after surgery of liver cancer].

Publisher: Gan To Kagaku Ryohosha Country of Publication: Japan NLM ID: 7810034 Publication Model: Print Cited Medium: Print ISSN: 0385-0684 (Print) Linking ISSN: 03850684 NLM ISO Abbreviation: Gan To Kagaku Ryoho Subsets: MEDLINE

Publication: Tokyo : Gan To Kagaku Ryohosha
Original Publication: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]-

Hepatectomy*; Antibiotics, Antineoplastic/*administration & dosage ; Carcinoma, Hepatocellular/*drug therapy ; Carcinoma, Hepatocellular/*secondary ; Epirubicin/*administration & dosage ; Liver Neoplasms/*pathology ; Lung Neoplasms/*drug therapy ; Lung Neoplasms/*secondary; Aged ; Drug Administration Schedule ; Fluorouracil/administration & dosage ; Humans ; Liver Neoplasms/surgery ; Male ; Middle Aged

Case 1 was a 55-year-old male with multiple pulmonary metastases after two operations to excise hepatocellular carcinoma. Treatment consisted of initial administration of 5'-DFUR (po), followed by frequent administration of low-dose epirubicin (20 mg/body once every 2 weeks iv). This resulted in disappearance of the pulmonary metastases and a striking decrease in the AFP level. Case 2 was a 68-year-old male with multiple pulmonary metastases after surgery for hepatocellular carcinoma. Treatment with 5-FU (iv; once a week) and epirubicin (20 mg/body once every 2 weeks iv) resulted in disappearance of the pulmonary metastases and a marked decrease in the AFP level. It was concluded that administration of epirubicin in frequent, low doses is a useful method for the treatment of pulmonary metastasis after surgery for liver cancer, and it can be safely performed even on an outpatient basis.

0 (Antibiotics, Antineoplastic)
3Z8479ZZ5X (Epirubicin)
U3P01618RT (Fluorouracil)

Date Created: 19951001 Date Completed: 19951120 Latest Revision: 20131121

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