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Hypoglycemic Effect of Extracts from Cichorium glandulosum.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Xin Xue-lei1,2; Wu Han-kui1,2; L. V. Qiao-ying1,2; Haji, Akber Aisa1,2
- Source:
Natural Product Research & Development. Feb2012, Vol. 24 Issue 2, p234-238. 5p.- Subject Terms:
- Source:
- Additional Information
- Abstract: In this paper, eleven components of Cichorium glandulosum Boiss et Hout were prepared, and their hypoglycemic effects were tested by using protein tyrosine phosphatase 1B (PTP1 B), α-glucosidase, and AGE-BSA Non-enzyme Glycolysis inhibitor assay methods. The results showed us that all of the extracts are PTP1B inhihitors, and IC50 of the most active one is only 5.8 ± 0. 15 µg/mL Five of them are α-glucosidase inhibitor, and only CGS-I is an AGE-BSA Non-enzyme Glycolysis inhibitor. Then, the mechanism of CGS-1 was investigated on CHO cell line which transiently transfected with pJ3H-PTP1 B, and accumulated phosphor-AKT were observed in the cell, which may indicate that this is the pathway for anti-diabetes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Natural Product Research & Development is the property of Nature Product Research & Development and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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