Hypoglycemic Effect of Extracts from Cichorium glandulosum.

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    • Abstract:
      In this paper, eleven components of Cichorium glandulosum Boiss et Hout were prepared, and their hypoglycemic effects were tested by using protein tyrosine phosphatase 1B (PTP1 B), α-glucosidase, and AGE-BSA Non-enzyme Glycolysis inhibitor assay methods. The results showed us that all of the extracts are PTP1B inhihitors, and IC50 of the most active one is only 5.8 ± 0. 15 µg/mL Five of them are α-glucosidase inhibitor, and only CGS-I is an AGE-BSA Non-enzyme Glycolysis inhibitor. Then, the mechanism of CGS-1 was investigated on CHO cell line which transiently transfected with pJ3H-PTP1 B, and accumulated phosphor-AKT were observed in the cell, which may indicate that this is the pathway for anti-diabetes. [ABSTRACT FROM AUTHOR]
    • Abstract:
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