Distribution of complement C'2 and C'6 types in Australian cases of diabetes mellitus.

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  • Author(s): Kirk RL; Ranford PR; Court J; Zimmet P
  • Source:
    The Medical journal of Australia [Med J Aust] 1980 Nov 29; Vol. 2 (11), pp. 614-5.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Australasian Medical Publishing Co Country of Publication: Australia NLM ID: 0400714 Publication Model: Print Cited Medium: Print ISSN: 0025-729X (Print) Linking ISSN: 0025729X NLM ISO Abbreviation: Med J Aust Subsets: MEDLINE
    • Publication Information:
      Publication: : Pyrmont, NSW : Australasian Medical Publishing Co.
      Original Publication: Sydney : Australasian Medical Pub. Co.
    • Subject Terms:
      Complement C2/*genetics ; Complement C6/*genetics ; Diabetes Mellitus/*genetics ; Diabetes Mellitus, Type 1/*genetics; Alleles ; Australia ; Child ; HLA Antigens/genetics ; Humans ; Middle Aged ; Phenotype
    • Abstract:
      A series of patients with juvenile onset diabetes (IDDM) and mature onset diabetes (NIDDM) have been typed for genetic variants of two sets of complement factors. For the HLA-linked C'2 system, there was found a significant increase of the C'2 2-1 type in IDDM compared with NIDDM patients or healthy controls. No such increase in any phenotype was observed for the non-HLA-linked C'6 system. These observations emphasize again the genetic distinction between IDDM and NIDDM, and the role of chromosome 6 in controlling susceptibility to the insulin-dependent form of the disease.
    • Grant Information:
      R01 AM25446 United States AM NIADDK NIH HHS
    • Accession Number:
      0 (Complement C2)
      0 (Complement C6)
      0 (HLA Antigens)
    • Publication Date:
      Date Created: 19801129 Date Completed: 19810424 Latest Revision: 20210107
    • Publication Date:
      20221213
    • Accession Number:
      10.5694/j.1326-5377.1980.tb77064.x
    • Accession Number:
      7464619