Comparative pharmacokinetics and pharmacodynamics of cardiac glycosides.

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  • Author(s): Kelman AW; Sumner DJ; Lonsdale M; Lawrence JR; Whiting B
  • Source:
    British journal of clinical pharmacology [Br J Clin Pharmacol] 1980 Aug; Vol. 10 (2), pp. 135-43.
  • Publication Type:
    Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print Cited Medium: Print ISSN: 0306-5251 (Print) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: London, Macmillan Journals Ltd.
    • Subject Terms:
      Cardiac Glycosides/*metabolism; Adult ; Cardiac Glycosides/pharmacology ; Digoxin/metabolism ; Half-Life ; Heart Rate/drug effects ; Humans ; Kinetics ; Male ; Medigoxin/metabolism ; Ouabain/metabolism
    • Abstract:
      1 The pharmacokinetics and pharmacodynamics of ouabain, digoxinn and beta-methyl digoxin (medigoxin) have been investigated in a crossover study in four normal healthy volunteers. 2 Pharmacokinetics were studied using [3H]-labelled glycosides and the shortening of the left ventricular ejection time (LVET) was used as a measure of the effect of the drugs. A graded exercise protocol was used to correct for the effects of heart rate on LVET. 3 In three of the four subjects, both digoxin and beta-methyl digoxin produced a shortening in the LVET, but no such change could be detected with ouabain in any of the four subjects. 4 There was a good linear correlation between the shortening of the LVET and the amounts of digoxin or beta-methyl digoxin present in the body tissues. 5 One subject who showed no drug-related LVET shortening had greatly enhanced clearances of all three drugs studied.
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    • Accession Number:
      0 (Cardiac Glycosides)
      5ACL011P69 (Ouabain)
      73K4184T59 (Digoxin)
      I7GG1YUC5V (Medigoxin)
    • Publication Date:
      Date Created: 19800801 Date Completed: 19810116 Latest Revision: 20190512
    • Publication Date:
      20221213
    • Accession Number:
      PMC1430039
    • Accession Number:
      10.1111/j.1365-2125.1980.tb01730.x
    • Accession Number:
      7426275