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Selective decontamination of the digestive tract with norfloxacin in the prevention of ICU-acquired infections: a prospective randomized study.
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- Author(s): Ulrich, C.; Harinck-de Weerd, J.; Bakker, N.; Jacz, K.; Doornbos, L.; Ridder, V.; Harinck-de Weerd, J E; Bakker, N C; de Ridder, V A
- Source:
Intensive Care Medicine; Nov1989, Vol. 15 Issue 7, p424-431, 8p- Subject Terms:
BACTERIAL disease prevention; CROSS infection prevention; BACTERIAL diseases; NORFLOXACIN; COMPARATIVE studies; CROSS infection; DIGESTIVE organs; GRAM-negative bacteria; INTENSIVE care units; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PREANESTHETIC medication; RESEARCH; RESPIRATORY organs; EVALUATION research; RANDOMIZED controlled trials; DISEASE incidence; STANDARDS; THERAPEUTICS - Source:
- Additional Information
- Abstract: The efficacy of a relatively cheap regimen of selective decontamination (SDD) was evaluated in a diverse population of ICU patients. Patients requiring prolonged ICU stay (greater than 5 days) were randomly allocated to a treatment group or control group. Control patients (n = 52) received perioperative antimicrobial prophylaxis and antibiotic treatment was instituted only on sound clinical and bacteriological criteria. Treated patients (n = 48) received gastro-intestinal and oro-pharyngeal decontamination with polymyxin E, norfloxacin, amphotericin B and systemic antibiotic prophylaxis with trimethoprim until decontamination was achieved. The rate of gram-positive infections was not altered by SDD. The incidence of gram-negative respiratory tract, urinary tract and line infections was significantly reduced from 44%, 27% and 15% respectively in the control group to 6%, 4% and 0% in the treatment group. Mortality from nosocomial sepsis and overall mortality were also significantly reduced from 15% and 54% to 0% and 31% respectively. The ICU stay was not reduced by SDD, nor was time on the ventilator or use of therapeutic antibiotics. The reduction in morbidity and mortality was achieved at a relatively low cost. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Intensive Care Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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