Angiosarcoma of the liver: a signal lesion of vinyl chloride exposure.

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  • Author(s): Vianna NJ; Brady J; Harper P
  • Source:
    Environmental health perspectives [Environ Health Perspect] 1981 Oct; Vol. 41, pp. 207-10.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Hemangiosarcoma/*chemically induced ; Liver Neoplasms/*chemically induced ; Occupational Diseases/*chemically induced ; Vinyl Chloride/*adverse effects ; Vinyl Compounds/*adverse effects; Adolescent ; Adult ; Aged ; Female ; Fetal Death/chemically induced ; Humans ; Infant ; Male ; Middle Aged ; Neoplasms/chemically induced ; New York ; Pregnancy
    • Abstract:
      Vinyl chloride (VCM) induced angiosarcoma of the liver (ASL) is a rare vascular tumor which might be associated with a wide range of disease states. The possibility that this tumor might be a signal lesion is supported by mortality studies suggesting that cancers of the digestive, respiratory, neurological and lymphatic systems have occurred more often than expected in VCM workers. There is also evidence that certain non-neoplastic disorders, such as pneumoconiosis and excess fetal deaths, may be associated with this chemical. It has been suggested that a gradual increase in the incidence of ASL might have occurred in recent years. This could be a reflection of the long latency period and/or the increased recognition of this entity. Several cases of ASL have occurred in people living in the vicinity of VCM plants. This raises the possibility that low-level exposure to this chemical over a long period might induce ASL.
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    • Accession Number:
      0 (Vinyl Compounds)
      WD06X94M2D (Vinyl Chloride)
    • Publication Date:
      Date Created: 19811001 Date Completed: 19820527 Latest Revision: 20181113
    • Publication Date:
      20231215
    • Accession Number:
      PMC1568863
    • Accession Number:
      10.1289/ehp.8141207
    • Accession Number:
      7199428