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Mechanisms responsible for the altered cardiac repolarization dispersion in experimental hypothyroidism.
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- Author(s): Ferrer, T.; Arín, R. M.; Casis, E.; Torres-Jacome, J.; Sanchez-Chapula, J. A.; Casis, O.
- Source:
Acta Physiologica. Apr2012, Vol. 204 Issue 4, p502-512. 11p. 1 Black and White Photograph, 2 Charts, 8 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Aims: To identify the causes for the inhomogeneity of ventricular repolarization and increased QT dispersion in hypothyroid mice. Methods: We studied the effects of 5-propyl-2-thiouracil-induced hypothyroidism on the ECG, action potential (AP) and current density of the repolarizing potassium currents Ito,fast, Ito,slow, IK,slow and Iss in enzymatically isolated myocytes from three different regions of mouse heart: right ventricle (RV), epicardium of the left ventricle (Epi-LV) and interventricular septum. K+ currents were recorded with the patch-clamp technique. Membranes from isolated ventricular myocytes were extracted by centrifugation. Kv4.2, Kv4.3, KChIP and Na/Ca exchanger proteins were visualized by Western blot. Results: The frequency or conduction velocity was not changed by hypothyroidism, but QTc was prolonged. Neither resting membrane potential nor AP amplitude was modified. The action potential duration (APD)90 increased in the RV and Epi-LV, but not in the septum. Hypothyroid status has no effect either on Ito,slow, Ik,slow or Iss in any of the regions analysed. However, Ito,fast was significantly reduced in the Epi-LV and in the RV, whereas it was not altered in cells from the septum. Western blot analysis reveals a reduction in Kv4.2 and Kv4.3 protein levels in both the Epi-LV and the RV and an increase in Na/Ca exchanger. Conclusion: From these results we suggest that the regional differences in APD lengthening, and thus in repolarization inhomogeneity, induced by experimental hypothyroidism are at least partially explained by the uneven decrease in Ito,fast and the differences in the relative contribution of the depolarization-activated outward currents to the repolarization process. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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