Blocking HIV's Attack.

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  • Additional Information
    • Subject Terms:
      HIV infections; THERAPEUTICS; GENE therapy; DENDRITIC cells; T cells; HUMAN immunogenetics; HUMAN cell culture; GENETIC mutation; ZINC-finger protein genetics; CLINICAL trials; SAFETY
    • Abstract:
      The authors describe their research into a treatment for HIV that involves the engineering of immune cells for resistance against the virus. A system they developed of building artificial dendritic cells with magnetic beads for improved T cell culturing is discussed. Building on research findings that hereditary mutations of CCR5 proteins in some patients created HIV resistance by blocking the entry of the virus into T cells, they hope to combine gene editing of CCR5 by zinc finger proteins with their magnetic bead process to create a T-cell reinfusion treatment for HIV. An overview of clinical trials and safety studies using these methods is provided. INSETS: How HIV Enters an Immune Cell;Careful Editing Disables a Key Gene;Careful Editing Disables a Key Gene.