Novel bipodal, tripodal, and tetrapodal 1,4-dihydropyridines - Microwave-assisted synthesis and structural confinements.

The one pot, three component reaction of p-hydroxy benzaldehyde, β-ketoester, and ammonium acetate afforded the corresponding monopodal 1,4-dihydropyridines as building blocks, which in turn converted into diversified novel bipodal, tripodal, and tetrapodal 1,4-dihydropyridines with different alkylating agents through conventional as well as microwave assisted reactions. The unambiguous structural confinements of the all the synthesized compounds were drawn out with the help of 2D NMR (H-H COSY and C-H COSY). [ABSTRACT FROM AUTHOR]

La réaction monotope, à trois composants, du p-hydroxybenzaldéhyde, d′un β-cétoester et de l′acétate d′ammonium conduit aux 1,4-dihydropyridines correspondantes, des synthons monopodes qui, par le biais de réactions normales ou assistées par des microondes, peuvent être transformées à leur tour en nouvelles 1,4-dihydropyridines bipodes, tripodes et tétrapodes portant divers agents alkylants. Les confinements structuraux non ambiguës de tous les composés synthétisés ont été délimités à l′aide de la RMN 2D (COSY H-H et COSY C-H). [ABSTRACT FROM AUTHOR]

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