Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0364311 Publication Model: Print Cited Medium: Print ISSN: 0300-5623 (Print) Linking ISSN: 03005623 NLM ISO Abbreviation: Urol Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, Springer-Verlag.
    • Subject Terms:
      Butylhydroxybutylnitrosamine*/analogs & derivatives ; Carcinogens* ; Nitrosamines*; Urinary Bladder/*surgery ; Urinary Bladder Neoplasms/*chemically induced; Animals ; Cyclamates ; FANFT ; Male ; Neoplasms, Experimental/chemically induced ; Precancerous Conditions/chemically induced ; Rats ; Rats, Inbred F344 ; Saccharin ; Tryptophan/analogs & derivatives
    • Abstract:
      The effect of partial cystectomy on the occurrence of pre-neoplastic lesions, papillary or nodular hyperplasia (PN hyperplasia), of the bladder in male F344 rats was studied in an experiment in which bladder carcinogens and promoters were given to the rats after initiation with BBN. The bladder carcinogens tested were N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) and N-4[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and the bladder promoters were sodium saccharin, sodium cyclamate, and DL-tryptophan. Partial cystectomy significantly decreased the occurrence of PN hyperplasia in rats treated with EHBN and tended to inhibit that in rats given saccharin or tryptophan. Thus partial cystectomy inhibited rather than enhanced the induction of PN hyperplasia.
    • References:
      Am J Pathol. 1978 Apr;91(1):33-48. (PMID: 645820)
      Lab Invest. 1981 Sep;45(3):285-94. (PMID: 7278134)
      J Natl Cancer Inst. 1979 Dec;63(6):1411-6. (PMID: 117197)
      Acta Pathol Jpn. 1982 Mar;32(2):243-50. (PMID: 7090816)
      Gan. 1974 Dec;65(6):565-6. (PMID: 4465158)
      Gan. 1971 Oct;62(5):359-65. (PMID: 5168761)
      Chem Biol Interact. 1975 Sep;11(3):225-33. (PMID: 1157191)
      Gan. 1980 Aug;71(4):490-500. (PMID: 7429086)
      Gan. 1976 Apr;67(2):197-205. (PMID: 964552)
      Cancer Res. 1969 Dec;29(12):2219-28. (PMID: 5387262)
      Br J Cancer. 1947 Dec;1(4):379-82. (PMID: 18906315)
      Gan. 1980 Dec;71(6):832-42. (PMID: 7274629)
      Lab Invest. 1981 Feb;44(2):89-96. (PMID: 7464042)
      J Natl Cancer Inst. 1974 Oct;53(4):1093-7. (PMID: 4427390)
      Cancer Res. 1979 Apr;39(4):1207-17. (PMID: 421204)
      Am J Pathol. 1981 Mar;102(3):373-80. (PMID: 7212020)
      Cancer Res. 1976 Jul;36(7 PT 2):2508-11. (PMID: 1277158)
      Cancer Res. 1981 Aug;41(8):3100-3. (PMID: 7248968)
      Gan. 1969 Aug;60(4):401-10. (PMID: 5345658)
      Acta Pathol Jpn. 1981 Jul;31(4):535-43. (PMID: 7282361)
      Cancer Res. 1971 Oct;31(10):1506-12. (PMID: 4328739)
    • Accession Number:
      0 (Carcinogens)
      0 (Cyclamates)
      0 (Nitrosamines)
      3817-11-6 (Butylhydroxybutylnitrosamine)
      54897-62-0 (N-ethyl-N-(4-hydroxybutyl)nitrosamine)
      6519-66-0 (tryptophan ethyl ester)
      7N99PZG62O (FANFT)
      8DUH1N11BX (Tryptophan)
      FST467XS7D (Saccharin)
    • Publication Date:
      Date Created: 19820101 Date Completed: 19821218 Latest Revision: 20190913
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/BF00255952
    • Accession Number:
      7135697