Renal calcifications: a complication of long-term furosemide therapy in preterm infants.

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  • Additional Information
    • Source:
      Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print Cited Medium: Print ISSN: 0031-4005 (Print) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE
    • Publication Information:
      Publication: Elk Grove Village Il : American Academy of Pediatrics
      Original Publication: Springfield, Ill., Thomas.
    • Subject Terms:
      Furosemide/*adverse effects ; Infant, Premature, Diseases/*drug therapy ; Kidney Calculi/*chemically induced; Ductus Arteriosus, Patent/complications ; Furosemide/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/etiology ; Humans ; Infant ; Infant, Newborn ; Kidney Calculi/diagnostic imaging ; Kidney Calculi/metabolism ; Radiography ; Respiratory Distress Syndrome, Newborn/drug therapy
    • Abstract:
      During the last four years ten premature infants developed renal calcifications while receiving long-term furosemide therapy. The drug was used in infants with present ductus arteriosus and later in the same infants with chronic lung disease. They had received furosemide in a dose of at least 2 mg/kg/day for at least 12 days before calcifications were noted on abdominal roentgenograms. Calcifications included small flecks, isolated stones, staghorn calculi, and nephrocalcinosis. Analysis of stones received from our infants showed calcium oxalate and calcium phosphate. Infants who were not receiving furosemide had no calcifications. The infants with renal calcifications had rates of calcium excretion ten to 20 times that of normal, age-matched premature infants in our nursery. When chlorothiazide was given to the infants, in addition to furosemide, a four- to 15-fold decrease in calcium excretion and a radiologic dissolution of the renal calcifications were documented. It is concluded that furosemide, in doses of at least 2 mg/kg/day for at least 12 days can be associated with renal calcifications. The probable mechanism of the stone formation is hypercalciuria, primarily caused by furosemide.
    • Accession Number:
      7LXU5N7ZO5 (Furosemide)
    • Publication Date:
      Date Created: 19820901 Date Completed: 19821012 Latest Revision: 20161123
    • Publication Date:
      20231215
    • Accession Number:
      7110808