Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. III. Studies in animals with acute infections.

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  • Additional Information
    • Source:
      Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print Cited Medium: Print ISSN: 0019-2805 (Print) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Antibody Formation*; Trypanosoma brucei brucei/*immunology ; Trypanosomiasis, African/*immunology; Acute Disease ; Animals ; Blood/parasitology ; Female ; Hemolytic Plaque Technique ; Immunization, Passive ; Liver/immunology ; Mice ; Radioisotopes ; Rats ; Selenium ; Trypanosoma brucei brucei/growth & development ; Trypanosomiasis, African/parasitology ; Vaccination
    • Abstract:
      Using trypanosomes labelled with [75Se]-methionine a series of experiments was conducted to investigate antibody production in mice with acute fulminating T. brucei infections. As measured by the hepatic uptake of radiolabelled parasites, we were unable to demonstrate any evidence of antibody-mediated uptake by the liver in such mice. It was concluded that this was not due to impaired macrophage function but was caused by the inability of antibody production to cope with the massive parasitaemias produced by rapidly-replicating infections so that effective opsonization of the parasites did not occur. In contrast, a train of trypanosome which causes a more chronic infection, although initially having a similar replication, although initially having a similar replication rate, subsequently switched t a slower one and thereby allowed antibody to reach levels which permitted effective opsonization. There was no evidence that the parasite caused any significant suppression of antibody responses in these acute infections since inoculation with trypanosomes of one stock at the same time as vaccination with irradiated organisms of a second stock did not prevent the development of antibody to the latter, as measured by the hepatic uptake of radiolabelled parasites.
    • References:
      Exp Parasitol. 1968 Feb;22(1):112-21. (PMID: 5643353)
      Immunology. 1968 Apr;14(4):599-600. (PMID: 5653817)
      Trans R Soc Trop Med Hyg. 1969;63(4):490-4. (PMID: 5821269)
      Exp Parasitol. 1970 Dec;28(3):521-34. (PMID: 4993889)
      Exp Parasitol. 1976 Dec;40(3):427-31. (PMID: 976425)
      Immunology. 1979 Mar;36(3):415-20. (PMID: 437835)
      Nature. 1980 Jan 31;283(5746):476-8. (PMID: 7352025)
      Parasite Immunol. 1979 Winter;1(4):317-26. (PMID: 45126)
      Immunology. 1980 Aug;40(4):629-35. (PMID: 7429544)
    • Accession Number:
      0 (Radioisotopes)
      H6241UJ22B (Selenium)
    • Publication Date:
      Date Created: 19810801 Date Completed: 19811118 Latest Revision: 20181113
    • Publication Date:
      20250114
    • Accession Number:
      PMC1555072
    • Accession Number:
      7024109