Pre-emptive intrathecal quinidine alleviates spinal nerve ligation-induced peripheral neuropathic pain.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Abstract:
      Objectives Quinidine, a class I anti-arrhythmic agent, is a sodium channel blocker that is more potent than lidocaine and mexiletine. This study tested pre-emptive intrathecal quinidine to attenuate neuropathic pain induced by lumbar spinal nerve ligation (SNL). Methods Ninety-six adult male Sprague-Dawley rats were grouped equally ( n = 24 per group) as follows: group S (sham), removal of transverse process only; group L, SNL; group Q35, SNL pretreated with intrathecal quinidine 35 m m (50 µl); group Q70, SNL pretreated with intrathecal quinidine 70 m m (50 µl). Neuropathic pain was measured by thermal hyperalgesia and mechanical allodynia. Other measurements included dys-regulation of sodium channel Nav1.3 in dorsal root ganglion (DRG) and spinal microglia activation in spinal dorsal horn. Key findings Spinal nerve ligation induced abnormal mechanical allodynia and thermal hyperalgesia, up-regulated Nav1.3 in DRG, and activated microglia in spinal cord. Group Q70 showed attenuated thermal hyperalgesia ( P < 0.001) and mechanical allodynia ( P < 0.05) on postoperative day 5 (POD5) but not on POD7, reversed up-regulated expression of Nav1.3 on POD3 and POD7 in DRG and significantly attenuated microglia activation on POD7 ( P = 0.032) in spinal cord. Conclusions Pretreatment with intrathecal quinidine 70 m m before SNL attenuates nerve ligation-induced neuropathic pain. The duration of the effect is 5 days. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Pharmacy & Pharmacology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)