A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation.

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  • Additional Information
    • Subject Terms:
      T cells; GENETIC mutation; LYMPHOPROLIFERATIVE disorders
    • Abstract:
      Focuses on the inhibition of T cell development by a linker for activation of T cells (LAT) in mice. Link of polyclonal lymphoproliferation disorder with LAT mutation; Properties of transmembrane scaffolding protein LAT; Role of integrated phospholipase signaling in T cell development and homeostasis.