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West Ashley Library
Closed for Staff Day
Phone: (843) 766-6635
Wando Mount Pleasant Library
Closed for Staff Day
Phone: (843) 805-6888
Village Library
Closed for Staff Day
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed for Staff Day
Phone: (843) 889-3300
Otranto Road Library
Closed for Staff Day
Phone: (843) 572-4094
Mt. Pleasant Library
Closed for Staff Day
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Closed for Staff Day
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Folly Beach Library
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Phone: (843) 588-2001
Dorchester Road Library
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Phone: (843) 722-7550
Baxter-Patrick James Island
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Main Library
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Phone: (843) 805-6930
Bees Ferry West Ashley Library
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Fatal Epstein-Barr-virus-associated proliferation of donor B cells after treatment of acute graft-versus-host disease with a murine anti-T-cell antibody.
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- Author(s): Martin, Paul J.; Shulman, Howard M.; Schubach, William H.; Hansen, John A.; Fefer, Alexander; Miller, George; Thomas, E. Donnali; Martin, P J; Shulman, H M; Schubach, W H; Hansen, J A; Fefer, A; Miller, G; Thomas, E D
- Source:
Annals of Internal Medicine; Sep84, Vol. 101 Issue 3, p310-315, 6p, 2 Charts, 2 Graphs- Subject Terms:
- Source:
- Additional Information
- Abstract: Two patients with acute leukemia were treated with chemoradiotherapy and allogeneic bone marrow transplantation. Despite the prophylactic use of methotrexate after grafting, both patients developed severe graft-versus-host disease that was refractory to treatment with methylprednisolone. The graft-versus-host disease was then treated with a monoclonal antibody, 64.1, that reacts with a p19 antigen on human T cells. The disease responded dramatically to this treatment, but both patients subsequently developed a fatal polyclonal lymphoproliferative disorder arising in donor-derived B cells. Hybridization studies showed Epstein-Barr virus in both tumors. The combined effect of severe end-stage graft-versus-host disease and potent immunosuppressive therapy probably resulted in a progressive immunodeficiency syndrome that abrogated the T-cell-mediated surveillance mechanism that normally modulates the proliferation of Epstein-Barr-virus-infected B lymphocytes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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