An evaluation of the mechanism by which serotonergic activation depresses respiration.

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  • Author(s): Lundberg DB; Mueller RA; Breese GR
  • Source:
    The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1980 Mar; Vol. 212 (3), pp. 397-404.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : Bethesda, MD : American Society for Pharmacology and Experimental Therapeutics
      Original Publication: Baltimore : Williams & Wilkins
    • Subject Terms:
      Respiration/*drug effects ; Serotonin/*physiology; 5,7-Dihydroxytryptamine/pharmacology ; 5-Hydroxytryptophan/pharmacology ; Animals ; Aromatic Amino Acid Decarboxylase Inhibitors ; Benserazide/pharmacology ; Blood Pressure/drug effects ; Brain Chemistry/drug effects ; Carbon Dioxide/pharmacology ; Cisterna Magna ; Drug Interactions ; Female ; Glossopharyngeal Nerve/physiology ; Heart Rate/drug effects ; Injections ; Male ; Methoxydimethyltryptamines/pharmacology ; Rats ; Vagotomy
    • Abstract:
      The present investigation attempted to determine if the previously reported depression of respiration by serotonergic agonists was a result of peripheral or central nervous system drug effects. Systemic administration of 5-hydroxytryptophan (5-HTP) to pargyline-treated animals and 5-methoxy-N,N-di-methyltryptophan (5-MDMT) probably depress respiration secondary to central penetration of these drugs, since: 1) adult rats with biochemical evidence of partial destruction of central serotonergic neurons after neonatal intracisternal 5,7-dihydroxytryptamine were supersensitive to the respiratory depressing effect of 5-HTP and 5-MDMT; 2) the ventilatory effect of the serotonergic agonists was not reduced by surgical deafferentiation induced by bilateral transection of the glossopharyngeal nerves; 3) after sectioning of the vagus nerve, the absolute change produced by serotonergic agonists was less; however, the relative change was unaltered; and 4) inhibition of peripheral aromatic amino acid decarboxylase by RO-4-4602 significantly blunted the respiratory depressant activity of 5-HTP observed at 15 min but not that present 30 min after 5-HTP. The present fidings thus suggest that the cenvel by the activity of central serotonergic neurons.
    • Accession Number:
      0 (Aromatic Amino Acid Decarboxylase Inhibitors)
      0 (Methoxydimethyltryptamines)
      142M471B3J (Carbon Dioxide)
      31363-74-3 (5,7-Dihydroxytryptamine)
      333DO1RDJY (Serotonin)
      762OS3ZEJU (Benserazide)
      C1LJO185Q9 (5-Hydroxytryptophan)
    • Publication Date:
      Date Created: 19800301 Date Completed: 19800523 Latest Revision: 20141120
    • Publication Date:
      20221213
    • Accession Number:
      6965719