Trace analysis of sulfaquinoxaline in animal tissues by high-performance liquid chromatography.

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  • Author(s): Patthy M
  • Source:
    Journal of chromatography [J Chromatogr] 1983 Jun 10; Vol. 275 (1), pp. 115-25.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0427043 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: J Chromatogr Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier.
    • Subject Terms:
      Liver/*analysis ; Muscles/*analysis ; Sulfanilamides/*analysis ; Sulfaquinoxaline/*analysis; Administration, Oral ; Animals ; Chickens ; Chromatography, High Pressure Liquid ; Meat/analysis ; Microchemistry ; Sulfaquinoxaline/metabolism ; Sulfonamides/isolation & purification
    • Abstract:
      Sulfaquinoxaline (in combination with diaveridine as a potentiating agent) was administered orally to broilers, 4-5 weeks old, and sulfonamide residues were determined in muscle and liver at 0, 1, 2, 4, 6, 7, 8, and 10 days post-treatment, using ion-pair extraction followed by high-performance liquid chromatography with UV detection. Improved recoveries (ca. 80%, at the 10 ppb level) were obtained after liquefaction of the tissues by the addition of 8 M urea and sodium hydroxide, prior to ion-pair extraction. A withdrawal period of seven days was found necessary in order to reduce drug residues in muscle and liver to 10 ppb, a level without hazard to humans.
    • Accession Number:
      0 (Sulfanilamides)
      0 (Sulfonamides)
      WNW8115TM9 (Sulfaquinoxaline)
    • Publication Date:
      Date Created: 19830610 Date Completed: 19830923 Latest Revision: 20190629
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/s0378-4347(00)84350-9
    • Accession Number:
      6874858