Phorbol esters parallel effects on tumor promotion, insulin release and calcium ionophoresis.

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  • Author(s): Deleers M; Castagna M; Malaisse WJ
  • Source:
    Cancer letters [Cancer Lett] 1981 Nov; Vol. 14 (2), pp. 109-14.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print Cited Medium: Print ISSN: 0304-3835 (Print) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier Science Ireland
      Original Publication: Amsterdam, Elsevier/North-Holland.
    • Subject Terms:
      Carcinogens*; Calcium/*metabolism ; Insulin/*metabolism ; Phorbol Esters/*pharmacology ; Phorbols/*pharmacology; Animals ; Biological Transport ; Calcimycin/pharmacology ; Female ; In Vitro Techniques ; Insulin Secretion ; Langerhans Cells/drug effects ; Langerhans Cells/metabolism ; Liposomes/metabolism ; Rats ; Structure-Activity Relationship ; Time Factors ; Viscosity
    • Abstract:
      The tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol 12,13-didecanoate (PDD) both stimulated insulin release from rat pancreatic islets and facilitated ionophore-mediated calcium transport in liposomes, the latter effect not resulting from a change in viscosity of the liposomial matrix. Phorbol and 4 alpha-phorbol 12,13-didecanoate (4 alpha-PDD), which fail to cause tumor promotion, also failed to stimulate insulin release and ionophore-mediated calcium transport. An alteration of calcium transport may represent a fundamental event in both the early (insulin release) and late (tumor promotion) biological responses to phorbol esters.
    • Accession Number:
      0 (Carcinogens)
      0 (Insulin)
      0 (Liposomes)
      0 (Phorbol Esters)
      0 (Phorbols)
      37H9VM9WZL (Calcimycin)
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 19811101 Date Completed: 19820322 Latest Revision: 20190720
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/0304-3835(81)90119-1
    • Accession Number:
      6797722