Influence of the virulence of Mycobacterium tuberculosis on protection induced by bacille Calmette-Guérin in guinea pigs.

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  • Author(s): Hank JA; Chan JK; Edwards ML; Muller D; Smith DW
  • Source:
    The Journal of infectious diseases [J Infect Dis] 1981 May; Vol. 143 (5), pp. 734-8.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Print ISSN: 0022-1899 (Print) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2011- : Oxford : Oxford University Press
      Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
    • Subject Terms:
      Virulence*; BCG Vaccine/*therapeutic use ; Guinea Pigs/*microbiology ; Mycobacterium tuberculosis/*pathogenicity ; Tuberculosis/*therapy; Animals ; Female ; Humans ; Lung/pathology ; Male
    • Abstract:
      The protective efficacy of two bacille Calmette-Guérin (BCG) vaccines was examined in guinea pigs infected by the respiratory route with strains of Mycobacterium tuberculosis differing in virulence. Virulence was defined as the degree of tissue damage (weight) of primary lesions excised from lungs of unvaccinated guinea pigs killed 28-42 days after infection. Groups of animals vaccinated with BCG-Copenhagen (strain no. 1331), a vaccine of high potency, or those vaccinated with BCG-Prague (strain no. 725), an experimental vaccine of low potency, and groups given placebo were challenged six weeks later with one of three challenge strains differing in virulence. Protection was assessed from the difference in the number of tubercle bacilli recovered from excised primary lung lesions or from primary lesion-free lung lobes of vaccinated vs. unvaccinated animals. The virulence of the challenge strain influenced the efficacy of BCG vaccination; however, the results of other studies with a laboratory strain were in general replicated.
    • Grant Information:
      AI-07485 United States AI NIAID NIH HHS
    • Accession Number:
      0 (BCG Vaccine)
    • Publication Date:
      Date Created: 19810501 Date Completed: 19810820 Latest Revision: 20190511
    • Publication Date:
      20221213
    • Accession Number:
      10.1093/infdis/143.5.734
    • Accession Number:
      6787142