[Effect of Brucella abortus on growth of ovarian granulosa cell carcinoma].

Vliianie Brucella abortus na rost granulezokletochnoĭ kartsinomy iaichnika.

Publisher: Administrativnoia Zdaniia Minzdrava Sssr Country of Publication: Russia (Federation) NLM ID: 0370627 Publication Model: Print Cited Medium: Print ISSN: 0365-9615 (Print) Linking ISSN: 03659615 NLM ISO Abbreviation: Biull Eksp Biol Med Subsets: MEDLINE

Publication: Moskva : Administrativnoia Zdaniia Minzdrava Sssr
Original Publication: Moskva, Medgiz.

Brucella abortus*; Brucella Vaccine/*therapeutic use ; Granulosa Cell Tumor/*therapy ; Leukemia, Experimental/*prevention & control ; Ovarian Neoplasms/*therapy; Animals ; Brucella Vaccine/administration & dosage ; Female ; Immunization, Passive ; Injections, Intraperitoneal ; Injections, Intravenous ; Injections, Subcutaneous ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Inbred Strains ; Rauscher Virus ; Time Factors

Live brucellosis vaccine Brucella abortus administered intraperitoneally, intravenously, subcutaneously or into the tumorous node inhibits the growth of granular cell ovarian carcinoma OC-1-72. The inhibitory effect depends on the B. abortus dose and tumor size. Pretreatment with B. abortus led, in some experiments, to the stimulation of tumor growth. The similar action was demonstrated by killed B. abortus vaccine administered into the tumorous node. The inhibitory effect on tumor growth can be mediated through the peritoneal exudate cells and spleen cells. Serum and an extract from spleens of mice infected with B. abortus inhibit the development of Rauscher's viral leukemia.

0 (Brucella Vaccine)

Date Created: 19801101 Date Completed: 19810324 Latest Revision: 20201209

20231215

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